Due to a problem in the Intel® Quartus® Prime Pro Edition software version 21.1, burning Physical eFuses is not allowed. Only virtual eFuses are supported.
A patch is available to fix this problem for the Intel® Quartus® Prime Pro Edition software version 21.1. Download and install Patch 0.06 from the appropriate link below.
> Download patch Intel® Quartus® Prime Pro Edition 21.1 Patch 0.06 for Windows (.exe)
> Download patch Intel® Quartus® Prime Pro Edition 21.1 Patch 0.06 for Linux (.run)
> Download the Readme for Intel® Quartus® Prime Pro Edition 21.1 Patch 0.06 (.txt)
This patch is scheduled to be included in a future release of the Intel® Quartus® Prime Pro Edition software.